and “Characterization of zebrafish von Willebrand factor reveals conservation of domain structure, multimerization, and intracellular storage” by J. Zebrafish are ideal model animals for in vivo testing of anti-obesity NPs, and disease models of several types of obesity have been developed. Maintaining the Barrier Function of Blood Vessels. I. Zebrafish are a promising model for obesity research, as lipid metabolism pathways are conserved between mammals and fish [44–46].Zebrafish have the key organs that are important for energy homeostasis and metabolism in mammals, as well as other key functions such as appetite regulation in the brain , insulin regulation , endocrine signaling through leptin , and … The present review provides a brief overview of recent studies on wild‐type and transgenic zebrafish as a model system to monitor toxic heavy metals, endocrine disruptors, and organic pollutants for toxicology. Zebrafish are ideal model animals for in vivo testing of anti-obesity NPs, and disease models of several types of obesity have been developed. Enter the email address you signed up with and we'll email you a reset link. Over the past 40 years, the development of methods for genetic and developmental manipulation have driven a rapid rise … In this review, we discuss the zebrafish inflammatory repertoire, and the main studies using zebrafish as a model of inflammation. Although the mouse remains the preclinical model of choice, in … The zebrafish has been widely used as a prominent model organism in different fields because of its small size, low cost, diverse adaptability, short breeding cycle, high fecundity, and transparent embryos. cluded. We also highlight pharmacological approaches using zebrafish as an experimental organism. Zebrafish: An Emerging Model System for Human Disease and Drug Discovery, High-Content Screening: Flow Cytometry Analysis, Phenotype-driven chemical screening in zebrafish for collective cell migration inhibitors identifies multiple potential pathways for targeting metastasis, Zebrafish-As an integrative model for twenty-first century toxicity testing, Whole-Animal High-Throughput Screens: The C. elegans Model. The zebrafish was first proposed as an animal model for studying genetics and human disease in a pair of papers in 1981 and 1983 by George Streisinger, a molecular biologist at the University of Oregon. Review papers, or studies that did not include tracts and fractions in multiwell-plates, often with the EDA procedure or zebrafish bioassays, were ex- exposure of several individuals in the same well (Table 2). This unique set of attributes makes the zebrafish model system particularly valuable for the study of muscle diseases. Over the past decades, the zebrafish has emerged as a powerful vertebrate model that has led to fundamental discoveries in developmental neurobiology and behavioral genetics. Zebrafish have a rich history as a model of vertebrate biology [ 14 ]. The zebrafish model has recently emerged as a significant experimental system for developmental biology studies. Zebrafish (Danio rerio), a small tropical freshwater vertebrate, is emerging as a recognized biological model to improve our knowledge of the molecular and cellular mechanisms of different pathological conditions. Recently, zebrafish … Purpose of review: Both traditional and novel cancer therapies can cause cardiovascular toxicity in patients. III. Zebrafish as a Model for Studying Hemorrhage and Stroke. The zebrafish provides an efficient model to leverage genetic analysis in an in vivo context. Introduction and Basic Concepts. For drug discovery, zebrafish are especially valuable in the earlier stages of research as they provide a model organism to … However, the evidence for zebrafish as an anti-obesity drug screening model are still limited. Its current uses and key techniques that highlight future areas of development of the system are also discussed. In vivo models integrating both cardiovascular and cancer phenotypes allow for the study of on- and off-target mechanisms of toxicity arising from these agents. Zebrafish as a Cardiac Model Morphological Characteristics. Inflammatory cells in zebrafish. In the past two decades, Zebrafish has become one of the preferred in vivo model organisms for studying diverse processes like regeneration , embryogenesis [9, 10], autophagy , behaviour [12, 13] and sleep.Recently, Zebrafish has sparked interest in other … The Special Issue will explore the diverse capabilities of the zebrafish model that can be applied to study a growing list of biological and preclinical research problems. The use of a zebrafish melanoma model to detect immune responses. Unlimited viewing of the article/chapter PDF and any associated supplements and figures. II. However, the evidence for zebrafish as an anti-obesity drug screening model are still limited. We then used the Ensembl genome viewer to identify the protein … (Mol Cancer Res 2008;6(5):685–94) The zebrafish has developed into an important model organism for biomedical research over the last decades. Zebrafish are an appropriate model to study human diseases, including obesity and related metabolic diseases, as pathways important for adipogenesis and lipid metabolism which are conserved between mammals and fish. The … © 2018 by John Wiley & Sons, Inc. The targeted gene knockout technique is a powerful tool to study the functions of these factors. Here I review the background and history leading to the popularity of zebrafish as a genetic model for investigating vertebrate embryonic development and preview how zebrafish research has expanded into other areas. The zebrafish was the first vertebrate to be cloned [ 15] and throughout the 1980’s and 90’s found widespread use as a model of vertebrate development [ 16–18 ]. Enter your email address below and we will send you your username, If the address matches an existing account you will receive an email with instructions to retrieve your username, Current Protocols Essential Laboratory Techniques, Current Protocols in Food Analytical Chemistry, Current Protocols in Magnetic Resonance Imaging, Current Protocols in Nucleic Acid Chemistry, I have read and accept the Wiley Online Library Terms and Conditions of Use. The zebrafish is also being used as a model for viral and parasitic diseases, including those that infect humans (Crim & Riley, 2012; Gratacap & Wheeler, 2014). Fast NMPC schemes for regulatory and economic NMPC – A review Journal of Process Control, Volume 44, August … View the article PDF and any associated supplements and figures for a period of 48 hours. To evaluate zebrafish as a potential model to study schizophrenia-associated CNVs, we first performed literature reviews to identify the human genomic regions spanning the CNVs. Kyzar and Kalueff’s article titled “Exploring Hallucinogen Pharmacology and Psychedelic Medicine with Zebrafish Models” makes a case for “the utility of this aquatic model organism in future experiments investigating the potential behavioral benefits and pharmacological toxicity of hallucinogenic compounds.” 9 Their article appeared in Zebrafish, a peer-reviewed journal … With the development of new genetic and analytical tools to better assay aspects of skeletal … Finally, an introduction to the essentials of zebrafish use and care are presented, highlighting the ease of adoption of this system for teaching and research use. These agents below to share a full-text version of this article with your personal account, please in... Several aspects of zebrafish as a model for high- through phenotyping study the functions of factors!, biotic and abiotic habitats, and disease models of several types of have! 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