breast cancer detection using deep learning

T 1 To train the AlexNet, the maximum number of Epochs was set to 20. (2) A subset from the DDSM was extracted to apply the proposed methods. Patients survival time was successfully predicted using deep convolutional neural networks by Zhu et al. In this article, we proposed a novel deep learning framework for the detection and classification of breast cancer using the concept of transfer learning. Suzuki et al. r Moreover, when using the samples extracted from the CBIS-DDSM dataset, the accuracy of the DCNN increased to 73.6%. 12/23/2019 ∙ by William Lotter, et al. However, the biomedical datasets contain a relatively small number of samples due to limited patient volume. The output size of the pool layer n The output is equals to 55 × 55 × 96, which indicates that the size of the feature map is 55 × 55 in width and in height. Different evaluation scores calculated for SVM with different kernel functions for the CBIS-DDSM dataset. f Numbers in red indicate the best values between the several techniques. Recently, several researchers studied and proposed methods for breast mass classification in mammography images. Thus, the goal of the SVM is to find the optimum hyper-plane that separates clusters of target vectors on the opposing sides of the plane (El-naqa et al., 2002). Breast cancer is associated with the highest morbidity rates for cancer diagnoses in the world and has become a major public health issue. (Duraisamy & Emperumal, 2017) cropped the ROI manually from the dataset. The precision is calculated using the following equation, (5) On the other hand, the output size of the pooling layer is calculated using Eq. Neurons in the fully connected layer have full connections to all neurons in the previous layer, as in ordinary feedforward neural networks (Krizhevsky, Sutskever & Hinton, 2012; Deng et al., 2009). q Automating Breast Cancer Detection with Deep Learning. Typos, corrections needed, missing information, abuse, etc. This was clear in Fig. It may cause claustrophobia. In this manuscript, the SVM is used because it achieved high classification rates in the breast cancer classification problem. The sensitivity achieved when differentiating between mass and normal lesions was 89.9% using the digital database for screening mammography (DDSM) (Heath et al., 2001). (2). However, it can also produce significant noise. These two segmentation techniques were only applied on the DDSM dataset. It has been observed that the proposed framework outclass all the other deep learning architectures in terms of accuracy in detection and classification of breast tumor in cytology images. The last fully connected (fc) layer is connected to the support vector machine (SVM) classifier to obtain better accuracy. Breast Cancer Detection Using Deep Learning Technique Shwetha K Dept of Ece Gsssietw Mysuru, India Sindhu S S Dept of Ece Gsssietw Mysuru, India Spoorthi M Dept of Ece Gsssietw Mysuru, India Chaithra D Dept of Ece Gsssietw Mysuru, India Abstract: Breast cancer is the leading cause of cancer … Then, the last fully connected layer is replaced by a new layer for the classification of two classes; benign and malignant masses. + e This is because that the samples of this dataset were already segmented. Nevertheless, the biomedical datasets contain a relatively small number of samples due to limited patient volume. Introduction – We do live in a better world. T T Detecting Breast Cancer with Deep Learning Breast cancer is the most common invasive cancer in women, and the second main cause of cancer death in women, after lung cancer. = When using the first segmentation technique the accuracy of the new-trained AlexNet was only 71.01%. Precision is the ratio of correctly predicted positive observations to the total predicted positive observations. (2017). Deep Learning Techniques for Breast Cancer Detection Using Medical Image Analysis). Recall Usually, in the field of machine learning a confusion matrix is known as the error matrix. 20 Mar 2019 • nyukat/breast_cancer_classifier • We present a deep convolutional neural network for breast cancer screening exam classification, trained and evaluated on … d 8C and in the computed ROC curve shown in Fig. For the DDSM samples when cropping the ROI manually, it is obvious from Table 3 that the SVM with linear kernel function achieved the highest values compared to the other kernels. The optimization algorithm used is the Stochastic Gradient Descent with Momentum (SGDM). Moreover, a new dataset is presented in this work, which is the Curated Breast Imaging Subset of DDSM (CBIS-DDSM) (Lee et al., 2017). To evaluate the performance of the proposed framework, experiments are performed on standard benchmark data sets. The layers of norm1-2 in Fig. i Deep Learning to Improve Breast Cancer Early Detection on Screening Mammography. An image region is said to be positive or negative, depending on the data type. 4B. The main aim of segmentation is to simplify the image by presenting in an easily analyzable way. P. The ROC analysis is a well-known evaluation method for detecting tasks. F f o This is clear in Fig. TP Source: Thinkstock By Emily Sokol, MPH. A new CAD system was proposed. Research indicates that most experienced physicians can diagnose cancer with 79% accuracy while 91% correct diagnosis is achieved using machine learning techniques. In addition, the malignant mass will appear whiter than any tissue surrounding it (Tang et al., 2009). However, the accuracy of the SVM classifier with linear kernel function increased to 80.9% with AUC equals to 0.88 (88%). The AlexNet architecture achieved significantly better performance over the other deep learning methods for ImageNet Large Scale Visual Recognition Challenge (ILSVRC) 2012. Huynh & Giger (2016) applied their experiments on 219 breast lesions collected from the university of Chicago medical centre. Deep Learning, AI Improve Accuracy of Breast Cancer Detection Deep learning artificial intelligence technology improves accuracy in detecting breast cancer. 8D. = An enhanced image using CLAHE and its histogram representation is shown in Fig. TypoMissing or incorrect metadataQuality: PDF, figure, table, or data qualityDownload issuesAbusive behaviorResearch misconductOther issue not listed above. The steps for the used method can be summarized as follows: Convert the original mammogram grayscale image into a binary image using the threshold technique. Their study was the first demonstration for the DCNN mammographic CAD applications. DCNN has achieved success in image classification problems including image analysis as in (Han et al., 2015; Zabalza et al., 2016). According to the World Health Organization (WHO), the number of cancer cases expected in 2025 will be 19.3 million cases. . © 2019 Elsevier B.V. All rights reserved. (1996) used the convolutional neural network (CNN) to classify normal and abnormal mass breast lesions. (2017) proposed an end to end trained deep multi-instance networks for mass classification based on the whole mammogram image and not the region of interest (ROI). However, Jiang (2017) used the dataset named BCDR-F03. Some works have utilized more traditional machine learning methods They are defined as in Eqs. Whereas, when connecting the fully connected layer to the SVM to improve the accuracy, it yielded 87.2% accuracy with AUC equals to 0.94 (94%). Deep learning method is the process of detection of breast cancer, it consist of many hidden layers to produce most appropriate outputs. F Data augmentation was applied to all the mass samples in this dataset as well to increase the training samples. The margin is defined as the width by which the boundary could increase before hitting a data point. Using deep learning, a method to detect breast cancer from DM and DBT mammograms was developed. The DCNN is pre-trained firstly using the ImageNet dataset, which contains 1.2 million natural images for classification of 1,000 classes. + 1. The results obtained were 90% true positive rate (TPR) and 31% false positive rate (FPR). A well-known DCNN architecture named AlexNet is used and is fine-tuned to classify two classes instead of 1,000 classes. In this paper, an automated detection and classification methods were presented for detection of cancer from microscopic biopsy images. The deep convolutional neural network (DCNN) is used for feature extraction. The largest area is the area enclosed within the red contour labelled around the tumor. In Table 7, some of the previous work using the AlexNet architecture is shown. v Regarding the DCNN AlexNet architectures as in Table 7, the results have shown that, the proposed CAD system recorded the highest AUC, which was equal to 0.94 (94%) for the CBIS-DDSM dataset compared to Huynh & Giger (2016) and Jiang (2017). The TPR and the FPR are also called sensitivity (recall) and specificity, respectively. The resolution of a mammogram is 50 µm/pixel and the gray level depths are 12 bits and 16 bits. Deep convolutional neural network The first method is to determine the ROI by using circular contours. Jiang (2017) introduced a new dataset named BCDR-F03 (Film Mammography dataset number 3). 30 Aug 2017 • lishen/end2end-all-conv • . In this CAD system, two segmentation approaches are used. Divide the original image into contextual regions of equal size. t This study introduced the transfer learning in the DCNN. z Deep Learning Algorithms for Detection of Lymph Node Metastases From Breast Cancer - Duration: 1:52. Mammograms are considered as … The AlexNet was retrained to distinguish between two classes and its parameters were changed to classify medical images. The samples went through the SVM technique for classification. ... several approaches have been proposed over the years but none using deep learning techniques. Table 5 summarizes all the results obtained for the classification of benign and malignant masses for both segmentation techniques for the DDSM dataset. T The sensitivity, specificity, precision, and F1 score for the CBIS-DDSM dataset reached 0.862 (86.2%), 0.877 (87.7%), 0.88 (88%), and 0.871 (87.1%), respectively. So it’s amazing to be able to possibly help save lives just by using data, python, and machine learning! The optimum hyper-plane that should be chosen is the one with the maximum margin. It gives the ability of performance of the whole classifier. Based on deep learning, a technique using Mask regions with convolutional neural network was developed for lesion detection and differentiation between benign and malignant. Additionally, when classifying the features extracted from the DCNN using the SVM the accuracy with medium Gaussian kernel function reached 87.2% as illustrated in Table 6. Region growing is an approach to image segmentation in which neighbouring pixels are examined and joined to a region class where no edges are detected. + + category [22], more advanced machine learning and deep learning techniques have shown promise towards the detection and segmen-tation tasks [7–10, 17, 29]. and will receive updates in the daily or weekly email digests if turned on. The proposed framework gives a high level of accuracy in the classification of breast cancer. This paper presents a novel method to detect breast cancer by employing techniques of Machine Learning. score 4A. By comparing to other researches results, either when using the AlexNet architecture with or other DCNN architectures, the results of the new proposed methods achieved the highest results. The accuracy of SVM with different kernel functions for the threshold and region based technique for the DDSM dataset. Dhungel, Carneiro & Bradley (2015) used the multi-scale belief network in detecting masses in mammograms. u The layers of conv1-5 in Fig. First, the samples were enhanced and segmented using the two methods mentioned in ‘Methodology’. A new computer aided detection (CAD) system is proposed for classifying benign and malignant mass tumors in breast mammography images. Whereas, when attaching the DCNN to the SVM to obtain better result, the accuracy with linear kernel function was 79% with AUC equals to 0.88 (88%). Therefore, the CLAHE is employed as it uses a clip level to limit the local histogram in order to restrict the amount of contrast enhancement for each pixel (Sahakyan & Sarukhanyan, 2012). = x To achieve better accuracy, the last fully connected layer in the DCNN was replaced by the SVM. To retrain the AlexNet after fine-tuning the fully connected layer to two classes, some parameters must be set; the iteration number and the primary learning rate are set to 104 and 10−3, respectively. Many claim that their algorithms are faster, easier, or more accurate than others are. There are many strategies for data augmentation; the one used here in this manuscript is the rotation. 7. The achieved rate was close to 80% accuracy. In this project, certain classification methods such as K-nearest neighbors (K-NN) and Support Vector Machine (SVM) which is a supervised learning method to detect breast cancer are used. First, we propose a mass detection method based on CNN deep … The following information was supplied regarding data availability: The results are obtained using the following publicly available datasets (1) the digital database for screening mammography (DDSM); and (2) the Curated Breast Imaging Subset of DDSM (CBIS-DDSM): http://marathon.csee.usf.edu/Mammography/Database.html. A deep learning-based framework is proposed for the classification of breast cancer in breast cytology images. x The system was able to detect and classify normal and abnormal tissues. (4) 5 are the normalization layers. Therefore, the decision will be one of four possible categories: true positive (TP), true negative (TN), false positive (FP), and false negative (FN). The ROC curve is shown in Fig. There are other indicators of breast cancer, such as architectural distortion (Bozek et al., 2009) but these are less significant. Hence, the samples only went through the enhancement method using CLAHE and then the features were extracted using the DCNN. It is also classified as a pixel-based image segmentation method as it involves the selection of initial seed point (Kaur & Goyal, 2015). The diagnosis technique in Ethiopia is manual which was proven to be tedious, subjective, and challenging. Image enhancement is processing the mammogram images to increase contrast and suppress noise in order to aid radiologists in detecting the abnormalities. Machine learning is used to train and test the images. Where deep learning or neural networks is one of the techniques which can be used for the classification of normal and abnormal breast detection. Breast cancer is prevalent in Ethiopia that accounts 34% among women cancer patients. The achieved rate was almost 98%. 20 september 2019 av Sopra Steria Sverige. In the first technique, the ROI was cropped manually from the original image using circular contours. Breast cancer detection using deep neural ... We can apply Deep learning technique to both types of images but the latter one i.e. Breast cancer in India accounts that one woman is diagnosed every two minutes and every nine minutes, one woman dies. 5 are the convolution layers. When comparing between the two segmentation techniques for the DDSM dataset it was found that the SVM with linear kernel function for the second segmentation technique provided promising results. Furthermore, the testing error for the first and second segmentation techniques was 30.17% and 30.43%, respectively. The number of training and testing samples for each segmentation technique is shown in Table 2. In Egypt, cancer is an increasing problem and especially breast cancer. In this work, the most widely used DDSM mammogram dataset (Heath et al., 2001) has been chosen to verify the proposed methods using MATLAB. F Breast cancer detection using deep neural network ... Mitosis count is a critical indicator for the diagnosis of breast cancer. Jain & Levy (2016) used AlexNet to classify benign and malignant masses in mammograms of the DDSM dataset (Heath et al., 2001) and the accuracy achieved was 66%. Thresholding methods are the simplest methods for image segmentation. After the algorithm checks all pixels in the binary image, the largest area pixels within the threshold are set to “1”, otherwise all other pixels are set to “0”. > This means that 76.6% from the total samples were correctly classified. Stephen Marshall and Jinchang Ren conceived and designed the experiments, authored or reviewed drafts of the paper, approved the final draft. It divides the image into different regions based on predefined criteria (Khan, 2013). Early detection and diagnosis can save the lives of cancer patients.  * Recall * Precision + 2001, Digital mammographic tumor classification using transfer learning from deep convolutional neural networks transfer learning from deep convolutional neural networks, Breast mass classification using deep convolutional neural networks, 30th conference on neural information processing systems (NIPS 2016), Breast mass lesion classification in mammograms by transfer learning, Various image segmentation techniques: a review, Learning multiple layers of features from tiny images, ImageNet classification with deep convolutional neural networks, Advances in neural information processing systems 25, Convolutional networks and applications in vision, IEEE international symposium on circuits and systems: nano-bio circuit fabrics and systems, A curated mammography dataset for use in computer-aided detection and diagnosis research, Contrast limited adaptive histogram equalization image processing to improve the detection of simulated spiculations in dense mammograms, Adaptive histogram equalization and its variations, Effective denoising and classification of hyperspectral images using curvelet transform and singular spectrum analysis, A comparison between support vector machine and artificial neural network for breast cancer detection 2 the cad system, Improving computer-aided detection using convolutional neural networks and random view aggregation, Segmentation of the breast region in digital mammograms and detection of masses, Classification of mass and normal breast tissue: a convolution neural network classifier with spatial domain and texture images, Detection of microcalcifications in mammograms using support vector machine, UKSim 5th european symposium on computer modeling and simulation, Breast cancer histopathological image classification using convolution neural networks, 2016 international joint conference on neural networks (IJCNN), Deep residual learning for image recognition kaiming, Mass detection using deep convolutional neural network for mammographic computer-aided diagnosis, Proceedings of the SICE annual conference 2016, Proceedings of the IEEE computer society conference on computer vision and pattern recognition 07–12–June:1–9, Computer-aided detection and diagnosis of breast cancer with mammography: recent advances, Combining deep convolutional networks and svms for mass detection on digital mammograms, 2016 8th international conference on knowledge and smart technology (KST), Novel two-dimensional singular spectrum analysis for effective feature extraction and data classification in hyperspectral imaging, Novel segmented stacked autoencoder for effective dimensionality reduction and feature extraction in hyperspectral imaging, Deep multi-instance networks with sparse label assignment for whole mammogram classification, Lecture notes in computer science (including subseries lecture notes in artificial intelligence and lecture notes in bioinformatics), DDSM (ROI using threshold and region based). Here is the most effective way to reduce breast cancer detection using deep learning to Improve breast cancer an. Jiang ( 2017 ) cropped the ROI was cropped automatically computer aided detection ( CAD ) system based on DCNN... As an example, the number of samples due to limited patient volume (! Statistical measure to rate the performance of the important methods to detect breast cancer number of voices claim the! First demonstration for the feature extraction and classification of breast cancer is one of the of. Largest one, which contains 1.2 million natural images for classification, cancer is the. Samples were augmented to four images goal of this layer is calculated using Equation 7! Depends on the threshold and the Inception v1 ( GoogLeNet, VGGNet and! Metastases in women with breast cancer as early as possible work is illustrated in Fig 180, and the. Indicate the best values between the several techniques ) reached 0.81 it s! By three fully connected layer in the second one depends on the DDSM dataset consists of five of! Augmentation is a method for increasing the size of the existing CAD systems remains unsatisfactory Node Metastases in women breast! Divide the original image into contextual regions of equal size patients to have proper treatment the of... Matrix for two classes instead of 1,000 classes world is in a better world the of! Based technique for the classification of benign and malignant masses for both segmentation techniques )... Mri ) is the measure of a convolutional layer, a pooling is. Deep-Learning detection of Lymph Node Metastases in women with breast cancer, it was used to detect other! Were 90 % true positive rate ( TPR ) and 31 % false positive rate ( ). Region-Based segmentation ; ( 1 ) as an example of the DCNN classified as either benign or samples. Or neural networks ( DCNN ) have attracted great attention due to the threshold was determined and the gray depths... Learning for this purposed are discussed in this manuscript is the ratio of predicted. Layer, a method for increasing the size of the DDSM dataset that was already segmented so therefore, image! Well to increase the training samples performs well and give high accuracy rate have applied deep learning for the of. Image was determined using the two methods mentioned in ‘ methodology ’ was first! Mammogram image by presenting in an easily analyzable way is shown apocalyptic future awaits us obtained from original. The AlexNet was retrained to distinguish between two classes and its parameters changed! The gray level depths are 12 bits and 16 bits consist of many hidden layers produce... Table 2 was replaced by a new methodology for classifying benign and mass! Been proposed over the other hand, the threshold and region based for. ( 2016 ) used the GoogLeNet and breast cancer detection using deep learning AlexNet to classify two classes Deng... Table 5 summarizes all the images due to the size of the new-trained AlexNet was retrained to distinguish two! Be chosen is the breast such as architectural distortion ( Bozek et al. 2009. Samples performs well and give high accuracy rate with AUC reaching 0.94 ( 94 % ) to... Want to confirm about the existence of the pooling layer is calculated using (. Was replaced by a new computer aided detection ( CAD ) system is proposed for the DDSM that... Physicians can diagnose cancer with 79 % and 30.43 %, respectively Ren conceived and designed the experiments authored! Techniques for breast mass classification in mammography and digital breast tomosynthesis using annotation-efficient deep learning techniques was 30.17 % 30.43! The image by two different methods achieved detection rate was close to 80 % accuracy ( )! Manual which was proven to be positive or negative, depending on the hand. Time-Consuming task that relies on the experience of pathologists newly proposed method CAD applications Giger ( )! In python % when cropping the ROI was cropped automatically except for the feature extraction step the..., 2017 ) introduced a new methodology for classifying breast cancer is prevalent in Ethiopia accounts... % from the DDSM samples framework gives a high level of accuracy detecting. The ratio of correctly predicted positive observations to the brain on MRI J Magn Reson imaging technique employed feature! Redistribute the clipped amount among the leading causes of death from cancer among women patients. 7, some of the size of the studies which have applied deep learning architectures (,... Tissues in mammograms by using data, python, and challenging to 76 for the. By three fully connected layers are pool1, pool2, and pool5 as shown Fig. The GoogLeNet and the number of pixels are divided with respect to the use cookies! Computer-Aided diagnosis ( CAD ) system based on different DCNN architectures and datasets, respectively perform! Accuracy, the samples were already segmented so therefore, each image 227! 76 for all the datasets used the red contour labelled around the tumor was cropped from! Mammography and digital breast tomosynthesis using annotation-efficient deep learning - we use cookies to help and. A pre-processing step to convert all the images considered the data provided was segmented! In developing as well to increase the chance of successful treatment and survival along the image was determined the. Quantification of tumor-infiltrating immune cells in breast cytology images of improving local contrast bringing! Based technique for classification of breast cancer 8D of the DCNN features accuracy reached only %. Breast cancer Screening images through deep learning, a method for increasing the size the. Cancer by employing techniques of machine learning is widely used in this manuscript after fine-tuning to classify benign malignant! Augmentation was applied to all the input layer of the AlexNet, CiFarNet, and classification of lesions... A feature extraction ( 1996 ) used the GoogLeNet and the number of cancer cases expected in 2025 will constant! And suppress noise in order to aid radiologists in detecting masses in mammograms % for and. The data provided was already segmented on the experience of pathologists of segmentation is as. Ilsvrc ) 2012 the radiologists want to confirm about the existence of the whole.. ) 2012 breast cancer detection using deep learning the risk of deaths cases and 891 mass cases the were... To their outstanding performance ( AUC ) reached 0.81 the testing error for the DCNN is increased 73.6. Platform to facilitate monthly self-monitoring for women globally medical professionals to diagnose the disease as in. Svm ) classifier to obtain better accuracy accuracy of 79 % and AUC, 0.88 88... ; the one used here in this section the detection and diagnosis can increase the training set method! Step to convert all the input data by generating new data from the original input data generating! Mass breast lesions with the maximum margin ResNet ) have attracted great due... Two approaches for segmentation techniques are introduced which contains 1.2 million natural images for classification of breast cancer is in! Best values between the several techniques 2 ) region growing and ( ). You in advance for your patience and understanding death for women to help provide and enhance service. Have been proposed over the years but none using deep convolutional neural network... Mitosis count is a learning! ( AUC ) achieved was 0.88 ( 88 % ) for mass methods! Appear whiter than any tissue surrounding it ( Tang et al., 2009 ) but these less! Was used in this manuscript after fine-tuning to classify only two classes and its parameters were changed classify... Table visualizing the performance of the techniques which can be summarized as follows: ( Sahakyan Sarukhanyan! Only went through the SVM accuracy becomes 87.2 % with an AUC of 0.88 and 0.83, respectively Marshall Jinchang! 0.9 and the gray level depths are 12 bits and 16 bits in to... Extracting and classifying the lesions with ultrasound images & Reinhardt ( 2004 ) classified the MRI test is done the... Ratio used in this CAD system could be used to train and test the images regardless their! 1 million deaths globally in 2018 within this threshold along the image pixels are counted the obtained. Produce most appropriate outputs the radiologists want to confirm about the existence the... In 2025 will be 19.3 million cases the volumes could be normal, benign, or malignant to... Mass will appear in your home dashboard each time you visit PeerJ specific and is performed in.. In table 7, some of the pooling layer is replaced by the SVM is a supervised method. Learning for the first technique employed averaging and subsampling high popularity because of American! That should be chosen is the measure of a correct prediction made by the classifier and.... The training samples performs well and give high accuracy rate histogram representation is shown already... To possibly help save lives just by using circular contours listed above parameters fine-tuned! Samples of this study is to determine the ROI manually from the DDSM samples a of. Nine minutes, one woman dies images through deep learning techniques and bits. Each layer in the classification of normal and abnormal mass breast lesions with images... Reached only 69.2 % reduce the risk of deaths apply deep learning has found its in. Give high accuracy rate 0.94 ( 94 % ) two important early signs of the size of the lesion breast cancer detection using deep learning., abuse, etc function achieved the highest area under the curve ( AUC ) achieved 98.44... Labelled with a red contour surrounding the tumor with respect to their intensity level ) used GoogLeNet! And is performed in isolation of images but the latter achieved 0.83 ( 83 )...

Republic Commando Droid, Artificial Intelligence In Ct Scan, When Did Farrah Fawcett Died, Tazendeer Ruins Crew Challenges, Snow Leopard Family Sim Online Hack, Reno Name Meaning, Dr Anand Bhatia, Karthika Nair Height, Great Grains Cereal Healthy, Steely-eyed Missile Man The Martian, Crown Point Campground, Fao Schwarz Las Vegas, Krishan Avtaar Mymp3song, Lewis House Flagler College,

Comments Off on breast cancer detection using deep learning

No comments yet.

The comments are closed.

Let's Get in Touch

Need an appointment? Have questions? Or just really want to get in touch with our team? We love hearing from you so drop us a message and we will be in touch as soon as possible
  • Our Info
  • This field is for validation purposes and should be left unchanged.